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B7.2 provides co-stimulatory functions in vivo in response to staphylococcal enterotoxin B.
- Source :
-
European journal of immunology [Eur J Immunol] 1995 Jul; Vol. 25 (7), pp. 2111-4. - Publication Year :
- 1995
-
Abstract
- Excessive T cell activation induced by bacterial superantigens plays an important role in the pathology associated with Gram-positive bacteremia. To gain insight into the early phases of T cell activation by bacterial enterotoxins in vivo, we investigated the ability of antibodies to well-defined co-stimulatory molecules to inhibit T cell activation and the subsequent toxic shock syndrome induced in BALB/c mice following the injection of staphylococcal enterotoxin B (SEB). We demonstrate here that a single dose of anti-B7.2 antibodies, but not anti-B7.1 antibodies, significantly inhibits T cell activation, as judged by lower systemic IL-2 release, blastogenesis and IL-2 receptor expression, and reduces the lethal effect of SEB in D-galactosamine-sensitized mice. These results demonstrate that co-stimulation through the B7.2 molecule plays an important role in the activation of T cells in response to SEB in vivo and suggest alternative therapies for septic shock caused by bacterial enterotoxins based on blocking antibodies to co-stimulatory molecules.
- Subjects :
- Animals
Antibodies, Monoclonal immunology
B7-2 Antigen
Clonal Anergy
Enterotoxins antagonists & inhibitors
Female
Lymphocyte Activation
Mice
Mice, Inbred BALB C
Spleen cytology
Antigens, CD
B7-1 Antigen physiology
Enterotoxins toxicity
Membrane Glycoproteins physiology
T-Lymphocytes immunology
Subjects
Details
- Language :
- English
- ISSN :
- 0014-2980
- Volume :
- 25
- Issue :
- 7
- Database :
- MEDLINE
- Journal :
- European journal of immunology
- Publication Type :
- Academic Journal
- Accession number :
- 7542606
- Full Text :
- https://doi.org/10.1002/eji.1830250747