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Role of heat shock protein 65/60 in the pathogenesis of atherosclerosis.
- Source :
-
International archives of allergy and immunology [Int Arch Allergy Immunol] 1995 May-Jun; Vol. 107 (1-3), pp. 130-1. - Publication Year :
- 1995
-
Abstract
- Investigations in rabbits and humans have provided experimental evidence that autoimmune reactions play a major role in the initial stages of the development of atherosclerosis. These involve the infiltration of the arterial intima with T cells reacting with heat shock protein (hsp) 65/60 and the occurrence of anti-hsp 65/60 antibodies. This early immunologically mediated stage of atherosclerosis is still reversible but if additional risk factors, such as high cholesterol levels, come into effect, severe mostly irreversible lesions develop.
- Subjects :
- Animals
Arteriosclerosis epidemiology
Arteriosclerosis immunology
Arteriosclerosis pathology
CD4-Positive T-Lymphocytes immunology
CD4-Positive T-Lymphocytes pathology
Cell Adhesion Molecules analysis
Chaperonin 60 immunology
Chaperonins immunology
Diet, Atherogenic
Humans
Intercellular Adhesion Molecule-1 analysis
Rabbits
Risk Factors
Vascular Cell Adhesion Molecule-1
Arteriosclerosis etiology
Bacterial Proteins
Chaperonin 60 physiology
Chaperonins physiology
Subjects
Details
- Language :
- English
- ISSN :
- 1018-2438
- Volume :
- 107
- Issue :
- 1-3
- Database :
- MEDLINE
- Journal :
- International archives of allergy and immunology
- Publication Type :
- Academic Journal
- Accession number :
- 7542057
- Full Text :
- https://doi.org/10.1159/000236952