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Depletion of brain serotonin by 5,7-DHT: effects on the 8-OH-DPAT-induced changes of sleep and waking in the rat.
- Source :
-
Psychopharmacology [Psychopharmacology (Berl)] 1994 Jun; Vol. 115 (1-2), pp. 273-7. - Publication Year :
- 1994
-
Abstract
- The effect of 5-HT1A receptor agonist 8-OH-DPAT on sleep and wakefulness was studied in rats with selective serotonin depletion after ICV administration of the neurotoxin 5,7-dihydroxytryptamine (5,7-DHT). Injection of 8-OH-DPAT to vehicle-treated animals induced biphasic effects, such that low doses (0.010 mg/kg) which act perferentially on the somatodendritic autoreceptor decreased wakefulness (W) and increased slow wave sleep (SWS), while higher doses (0.375 mg/kg) which stimulate postsynaptic receptors caused opposite effects. REM sleep was suppressed irrespective of the dosage given. Injection of the 0.010 mg/kg dose in the 5,7-DHT-treated rats did not result in significant changes in sleep or W. On the other hand, the 0.375 mg/kg dose produced changes in sleep variables which were similar to those described in the vehicle-treated animals. Our findings tend to indicate that increased SWS after low doses of 8-OH-DPAT depends upon the activation of inhibitory somatodendritic 5-HT1A receptors, while increased W after higher doses of the compound is related to stimulation of postsynaptic receptors.
- Subjects :
- Animals
Biogenic Monoamines metabolism
Dose-Response Relationship, Drug
Hydroxyindoleacetic Acid metabolism
Male
Rats
Rats, Wistar
Receptors, Presynaptic drug effects
Receptors, Serotonin drug effects
Serotonin physiology
Sleep, REM drug effects
5,7-Dihydroxytryptamine pharmacology
8-Hydroxy-2-(di-n-propylamino)tetralin pharmacology
Brain Chemistry drug effects
Serotonin metabolism
Sleep drug effects
Wakefulness drug effects
Subjects
Details
- Language :
- English
- ISSN :
- 0033-3158
- Volume :
- 115
- Issue :
- 1-2
- Database :
- MEDLINE
- Journal :
- Psychopharmacology
- Publication Type :
- Academic Journal
- Accession number :
- 7532312
- Full Text :
- https://doi.org/10.1007/BF02244783