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1'-(2-Phenyl-ethylene)-ditryptophenaline, a new dimeric diketopiperazine from Aspergillus flavus.
- Source :
-
Journal of natural products [J Nat Prod] 1994 Sep; Vol. 57 (9), pp. 1239-44. - Publication Year :
- 1994
-
Abstract
- A new diketopiperazine dimer, 1'-(2-phenyl-ethylene)-ditryptophenaline [1], was isolated together with ditryptophenaline [2] from the fungus Aspergillus flavus. The structure of 1 was determined by analysis of spectroscopic data. In contrast to the structurally related substance-P antagonist WIN 64821 [3], both 1 and 2 are weak substance-P inhibitors, indicating that stereochemistry at the position of dimerization is an important determinant of biological potency for these molecules.
Details
- Language :
- English
- ISSN :
- 0163-3864
- Volume :
- 57
- Issue :
- 9
- Database :
- MEDLINE
- Journal :
- Journal of natural products
- Publication Type :
- Academic Journal
- Accession number :
- 7528269
- Full Text :
- https://doi.org/10.1021/np50111a008