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Clinical and immunohistochemical studies of skin eruptions: relationship to administration of interferon-alpha.
- Source :
-
The Journal of dermatology [J Dermatol] 1994 Oct; Vol. 21 (10), pp. 732-7. - Publication Year :
- 1994
-
Abstract
- We observed transient, erythematous skin eruptions in 6 patients during the intravenous administration of interferon (INF)-alpha for chronic active hepatitis C. The eruptions appeared 5 to 14 days (mean: 6.8 days) after initiating its administration. They were localized or disseminated and consisted of edematous, erythematous, and/or papular changes. Vesicles and petechiae also appeared in some cases. The eruptions disappeared in 10 to 14 days, despite the continuance of INF-alpha and without specific treatment. Histological examination obtained from skin eruptions revealed perivascular infiltration of lymphoid cells, the majority which were CD4-positive, of the upper dermis. Edematous changes were present in the papillary dermis. Vascular endothelial cells in the upper dermis expressed both intercellular adhesion molecule-1 (ICAM-1) and endothelial leukocyte adhesion molecule-1 (ELAM-1), while the epidermal keratinocytes produced neither. These findings suggested a nonallergic mechanism for such eruptions.
- Subjects :
- Adult
Blister etiology
Blister pathology
CD4-Positive T-Lymphocytes pathology
Cell Adhesion
Cell Adhesion Molecules metabolism
E-Selectin
Edema etiology
Edema pathology
Endothelium, Vascular metabolism
Endothelium, Vascular pathology
Erythema etiology
Erythema pathology
Female
Hepatitis C therapy
Hepatitis, Chronic therapy
Humans
Immunohistochemistry
Injections, Intravenous
Intercellular Adhesion Molecule-1 metabolism
Interferon-alpha administration & dosage
Keratinocytes metabolism
Male
Middle Aged
Purpura etiology
Purpura pathology
Receptors, Immunologic metabolism
Skin pathology
Drug Eruptions etiology
Drug Eruptions pathology
Interferon-alpha adverse effects
Subjects
Details
- Language :
- English
- ISSN :
- 0385-2407
- Volume :
- 21
- Issue :
- 10
- Database :
- MEDLINE
- Journal :
- The Journal of dermatology
- Publication Type :
- Academic Journal
- Accession number :
- 7528230
- Full Text :
- https://doi.org/10.1111/j.1346-8138.1994.tb03278.x