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Treatment of alloimmune neonatal neutropenia with granulocyte colony-stimulating factor.
- Source :
-
The Journal of pediatrics [J Pediatr] 1994 Dec; Vol. 125 (6 Pt 1), pp. 948-51. - Publication Year :
- 1994
-
Abstract
- Despite numerous attempts to increase the neutrophil count of infants with alloimmune neonatal neutropenia, no therapy has been consistently effective. We describe two infants with alloimmune neutropenia who had a rapid and prolonged increase in neutrophil number after treatment with granulocyte colony-stimulating factor (G-CSF). Patient 1 had antibody directed against the neutrophil antigen NA2. He received three daily doses of G-CSF, and within 2 days his neutrophil count increased from 0.350 x 10(9) to 3.584 x 10(9)/L (350 to 3584/mm3). Despite cessation of treatment the neutrophil count remained in the normal range. Patient 2 had antibody to the neutrophil antigen NA1, and received six daily doses of G-CSF. Within 4 days his neutrophil count increased from 0.477 x 10(9) to 4.320 x 10(9)/L (477 to 4320/mm3) and remained in the normal range for 11 days after the last dose of G-CSF. We recommend that treatment with G-CSF be considered for selected infants with alloimmune neutropenia.
- Subjects :
- Follow-Up Studies
HLA-A1 Antigen blood
HLA-A1 Antigen immunology
HLA-A2 Antigen blood
HLA-A2 Antigen immunology
Humans
Immunoglobulin A blood
Immunoglobulin A immunology
Immunoglobulin G blood
Immunoglobulin G immunology
Immunoglobulin M blood
Immunoglobulin M immunology
Infant, Newborn
Isoantigens blood
Isoantigens immunology
Leukocyte Count
Male
Neutropenia immunology
Neutrophils immunology
Granulocyte Colony-Stimulating Factor therapeutic use
Neutropenia therapy
Subjects
Details
- Language :
- English
- ISSN :
- 0022-3476
- Volume :
- 125
- Issue :
- 6 Pt 1
- Database :
- MEDLINE
- Journal :
- The Journal of pediatrics
- Publication Type :
- Academic Journal
- Accession number :
- 7527850
- Full Text :
- https://doi.org/10.1016/s0022-3476(05)82014-1