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Histological and functional studies on the nitroxidergic nerve innervating monkey cerebral, mesenteric and temporal arteries.
- Source :
-
Japanese journal of pharmacology [Jpn J Pharmacol] 1994 Aug; Vol. 65 (4), pp. 351-9. - Publication Year :
- 1994
-
Abstract
- Nitroxidergic nerves and their functional role were determined in a variety of monkey arteries. Nitric oxide synthase-immunoreactive nerve fibers innervating the monkey arterial wall were histochemically determined by the use of nitric oxide synthase antiserum. Thin nitric oxide synthase-immunoreactive fibers were consistently found in the outer media of monkey cerebral, mesenteric and temporal arteries, in addition to many thicker fibers and nerve bundles in the adventitia. In the monkey pterygopalatine ganglion, the immunoreactivity was clearly seen in nerve cells, bundles and fibers. Helical strips of monkey arteries were exposed to the bathing media for tension recordings and were stimulated by electrical square pulses. In helical strips of the cerebral artery denuded of the endothelium, transmural electrical stimulation produced relaxations that were abolished by tetrodotoxin or NG-nitro-L-arginine, a nitric oxide synthase inhibitor. In the monkey mesenteric and temporal arterial strips treated with alpha-adrenoceptor antagonists, the relaxation caused by electrical stimulation was also abolished by the nitric oxide synthase inhibitor, and it was restored by L-arginine. Nitroxidergic perivascular nerves, histologically demonstrated, appear to play an important role in dilating the monkey cerebral artery and in counteracting a vasoconstriction associated with noradrenergic nerve activation in the mesenteric and temporal arteries.
- Subjects :
- Amino Acid Oxidoreductases metabolism
Analysis of Variance
Animals
Cerebral Arteries physiology
Electric Stimulation
Female
Immunohistochemistry
Macaca
Male
Mesenteric Arteries physiology
Nerve Fibers drug effects
Nerve Fibers metabolism
Nerve Fibers physiology
Nicotine pharmacology
Nitric Oxide Synthase
Temporal Arteries physiology
Vasodilation
Cerebral Arteries innervation
Mesenteric Arteries innervation
Nitric Oxide metabolism
Temporal Arteries innervation
Subjects
Details
- Language :
- English
- ISSN :
- 0021-5198
- Volume :
- 65
- Issue :
- 4
- Database :
- MEDLINE
- Journal :
- Japanese journal of pharmacology
- Publication Type :
- Academic Journal
- Accession number :
- 7527469
- Full Text :
- https://doi.org/10.1254/jjp.65.351