Back to Search
Start Over
Risperidone in the treatment of pervasive developmental disorder.
- Source :
-
Canadian journal of psychiatry. Revue canadienne de psychiatrie [Can J Psychiatry] 1994 Sep; Vol. 39 (7), pp. 400-5. - Publication Year :
- 1994
-
Abstract
- Elevated concentrations of blood serotonin have been documented in autistic children and mentally retarded adults. Antiserotonergic pharmacotherapy has been partially effective in treating a subgroup of children with autistic disorder. Therefore, the possibility is raised that an antiserotonergic treatment may be of value to adult psychiatric patients with a history of pervasive developmental disorder. Two such cases are described where the patients underwent psychiatric and neuropsychological examination before and after treatment with risperidone, a potent 5-HT2 antagonist with additional D2 antagonistic properties. Particular improvements were documented in both patients, despite long histories of cognitive compromise and high likelihood of damage to the central nervous system.
- Subjects :
- Adolescent
Adult
Antipsychotic Agents adverse effects
Autistic Disorder blood
Autistic Disorder drug therapy
Autistic Disorder psychology
Child
Child Development Disorders, Pervasive blood
Child Development Disorders, Pervasive psychology
Follow-Up Studies
Humans
Intellectual Disability blood
Intellectual Disability drug therapy
Intellectual Disability psychology
Isoxazoles adverse effects
Male
Neuropsychological Tests
Piperidines adverse effects
Risperidone
Serotonin blood
Stereotyped Behavior drug effects
Antipsychotic Agents therapeutic use
Child Development Disorders, Pervasive drug therapy
Isoxazoles therapeutic use
Piperidines therapeutic use
Subjects
Details
- Language :
- English
- ISSN :
- 0706-7437
- Volume :
- 39
- Issue :
- 7
- Database :
- MEDLINE
- Journal :
- Canadian journal of psychiatry. Revue canadienne de psychiatrie
- Publication Type :
- Academic Journal
- Accession number :
- 7527293
- Full Text :
- https://doi.org/10.1177/070674379403900703