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Risperidone in the treatment of pervasive developmental disorder.

Authors :
Purdon SE
Lit W
Labelle A
Jones BD
Source :
Canadian journal of psychiatry. Revue canadienne de psychiatrie [Can J Psychiatry] 1994 Sep; Vol. 39 (7), pp. 400-5.
Publication Year :
1994

Abstract

Elevated concentrations of blood serotonin have been documented in autistic children and mentally retarded adults. Antiserotonergic pharmacotherapy has been partially effective in treating a subgroup of children with autistic disorder. Therefore, the possibility is raised that an antiserotonergic treatment may be of value to adult psychiatric patients with a history of pervasive developmental disorder. Two such cases are described where the patients underwent psychiatric and neuropsychological examination before and after treatment with risperidone, a potent 5-HT2 antagonist with additional D2 antagonistic properties. Particular improvements were documented in both patients, despite long histories of cognitive compromise and high likelihood of damage to the central nervous system.

Details

Language :
English
ISSN :
0706-7437
Volume :
39
Issue :
7
Database :
MEDLINE
Journal :
Canadian journal of psychiatry. Revue canadienne de psychiatrie
Publication Type :
Academic Journal
Accession number :
7527293
Full Text :
https://doi.org/10.1177/070674379403900703