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Superoxide anion-induced histamine release from rat peritoneal mast cells.
- Source :
-
Biological & pharmaceutical bulletin [Biol Pharm Bull] 1994 May; Vol. 17 (5), pp. 732-4. - Publication Year :
- 1994
-
Abstract
- We investigated the properties of superoxide anion (O2-)-induced histamine release from rat peritoneal mast cells using superoxide anion radicals obtained from potassium superoxide (KO2). KO2 elicited a rapid histamine release in a dose-dependent fashion, without lactate dehydrogenase (LDH) release. The KO2-induced release was temperature- and energy-dependent. KO2 rapidly increased the intracellular free Ca2+ concentration, accompanied by a marked increase of Ca(2+)-uptake. These findings indicate that the increase in intracellular Ca2+ concentration is involved in the initiation of KO2-induced histamine release, and KO2 could be used as an agent of O2(-)-induced biological reactions.
Details
- Language :
- English
- ISSN :
- 0918-6158
- Volume :
- 17
- Issue :
- 5
- Database :
- MEDLINE
- Journal :
- Biological & pharmaceutical bulletin
- Publication Type :
- Academic Journal
- Accession number :
- 7522732
- Full Text :
- https://doi.org/10.1248/bpb.17.732