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Cystic fibrosis gene therapy.
- Source :
-
Current opinion in genetics & development [Curr Opin Genet Dev] 1994 Jun; Vol. 4 (3), pp. 466-71. - Publication Year :
- 1994
-
Abstract
- A variety of cystic fibrosis gene therapy approaches based on viral (adenovirus, retrovirus, and adeno-associated virus) and non-viral (liposomes and receptor-mediated endocytosis) routes are currently being assessed for safety and efficacy. Of these, the trials involving liposomal and adenoviral vectors are the most advanced, as both have been shown to correct the cystic fibrosis Cl- conductance defect in vivo.
- Subjects :
- Adenoviruses, Human genetics
Animals
Chloride Channels genetics
Clinical Trials as Topic
Cystic Fibrosis genetics
Cystic Fibrosis Transmembrane Conductance Regulator
DNA, Complementary administration & dosage
DNA, Complementary genetics
Dependovirus genetics
Disease Models, Animal
Endocytosis
Genetic Vectors
Humans
Liposomes
Membrane Proteins genetics
Retroviridae genetics
Cystic Fibrosis therapy
Genetic Therapy methods
Subjects
Details
- Language :
- English
- ISSN :
- 0959-437X
- Volume :
- 4
- Issue :
- 3
- Database :
- MEDLINE
- Journal :
- Current opinion in genetics & development
- Publication Type :
- Academic Journal
- Accession number :
- 7522673
- Full Text :
- https://doi.org/10.1016/0959-437x(94)90037-x