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[Effective measures against side effects by increasing ACNU dose for malignant glioma: effects on digestive organs].
- Source :
-
Gan to kagaku ryoho. Cancer & chemotherapy [Gan To Kagaku Ryoho] 1994 Sep; Vol. 21 (12), pp. 2029-33. - Publication Year :
- 1994
-
Abstract
- Loading therapy consisting of the ACNU regimen was instituted as postoperative anticancer chemotherapy for malignant gliomas. The efficacy rate of the regimen was 25% at a dose of 3 mg/kg. A high incidence of hematological changes, such as leukopenia (neutropenia) and thrombocytopenia, were observed after chemotherapy. The former could be prevented by the administration of G-CSF, but platelet infusions were necessary in some patients for amelioration of thrombocytopenia. Gastroenterological symptoms, such as nausea and vomiting, were also frequently noted. Granisetron (Kytril), which is a recently developed selective competitive inhibitor of the 5-HT3 receptor, was used for the treatment of these adverse effects, and was found to be clinically effective.
- Subjects :
- Adult
Aged
Brain Neoplasms pathology
Drug Therapy, Combination
Female
Glioma pathology
Granulocyte Colony-Stimulating Factor administration & dosage
Humans
Male
Middle Aged
Nausea chemically induced
Vomiting chemically induced
Anorexia chemically induced
Brain Neoplasms drug therapy
Glioma drug therapy
Granisetron administration & dosage
Nimustine administration & dosage
Nimustine adverse effects
Subjects
Details
- Language :
- Japanese
- ISSN :
- 0385-0684
- Volume :
- 21
- Issue :
- 12
- Database :
- MEDLINE
- Journal :
- Gan to kagaku ryoho. Cancer & chemotherapy
- Publication Type :
- Academic Journal
- Accession number :
- 7522001