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Alteration in the antigenic structure of M1 protein of influenza A virus mutant resistant to a new antiviral compound mopyridone.
- Source :
-
Acta virologica [Acta Virol] 1994 Feb; Vol. 38 (1), pp. 5-10. - Publication Year :
- 1994
-
Abstract
- Using 14 monoclonal antibodies (MoAbs) in solid-phase ELISA it was found that influenza virus A/Hong Kong/1/68 (H3N2) mutants resistant to the antiviral compound mopyridone as compared to the mopyridone-sensitive mutant manifested significant changes in the antigenic structure (sites 1A, 2 and 3) of M1 protein. No differences in M1 were found between rimantadine-resistant and rimantadine-sensitive mutants of influenza virus A(H3N2).
- Subjects :
- Animals
Antibodies, Monoclonal
Antibodies, Viral
Antigens, Viral immunology
Chick Embryo
Drug Resistance, Microbial
Enzyme-Linked Immunosorbent Assay
Epitopes immunology
Influenza A virus drug effects
Mutation
Rimantadine pharmacology
Antiviral Agents pharmacology
Influenza A virus immunology
Pyrimidinones pharmacology
Viral Matrix Proteins immunology
Subjects
Details
- Language :
- English
- ISSN :
- 0001-723X
- Volume :
- 38
- Issue :
- 1
- Database :
- MEDLINE
- Journal :
- Acta virologica
- Publication Type :
- Academic Journal
- Accession number :
- 7520664