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KP-1: not a specific marker. Staining of 137 sarcomas, 48 lymphomas, 28 carcinomas, 7 malignant melanomas and 8 cystosarcoma phyllodes.
- Source :
-
Virchows Archiv : an international journal of pathology [Virchows Arch] 1994; Vol. 424 (6), pp. 635-40. - Publication Year :
- 1994
-
Abstract
- This study documents the reactions of the monoclonal antibody KP-1, which detects histiocytes in paraffin sections, with 137 sarcomas, 48 lymphomas, 28 carcinomas, 7 malignant melanomas and 8 cystosarcoma phyllodes. The soft tissue sarcomas had been previously immunophenotyped. Positive staining was obtained in all categories of sarcoma except clear-cell sarcomas. Most categories of sarcoma showed staining in less than 10% of tumour cells although a minority of leiomyosarcomas showed more extensive staining. Five of 7 malignant melanomas were also positive while all lymphomas and carcinomas were negative. We conclude that KP-1 positivity is not helpful in supporting the histiocytic origin of a tumour and is of limited value in the differential diagnosis of soft tissue sarcomas or their separation from other categories of malignancy.
- Subjects :
- Female
Humans
Staining and Labeling
Antigens, CD analysis
Antigens, Differentiation, Myelomonocytic analysis
Biomarkers, Tumor analysis
Breast Neoplasms chemistry
Carcinoma chemistry
Lymphoma chemistry
Melanoma chemistry
Phyllodes Tumor chemistry
Sarcoma chemistry
Soft Tissue Neoplasms chemistry
Subjects
Details
- Language :
- English
- ISSN :
- 0945-6317
- Volume :
- 424
- Issue :
- 6
- Database :
- MEDLINE
- Journal :
- Virchows Archiv : an international journal of pathology
- Publication Type :
- Academic Journal
- Accession number :
- 7519954
- Full Text :
- https://doi.org/10.1007/BF00195778