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Todralazine influence upon the mutagenicity of some direct- and indirect-acting mutagens.
- Source :
-
Mutation research [Mutat Res] 1994 Jul; Vol. 324 (3), pp. 133-7. - Publication Year :
- 1994
-
Abstract
- Todralazine decreased the mutagenic activity of tested direct- and indirect-acting mutagens. Despite the marked differences between efficient todralazine doses (ED50) it was observed that, in the case of tested indirect mutagens as well as in some of the direct mutagens, the decrease of mutagenicity by todralazine was very strong, exceeding 80% in some cases.
- Subjects :
- 4-Nitroquinoline-1-oxide toxicity
9,10-Dimethyl-1,2-benzanthracene antagonists & inhibitors
Aminacrine toxicity
Azides antagonists & inhibitors
Benzo(a)pyrene antagonists & inhibitors
Biotransformation
Daunorubicin antagonists & inhibitors
Dose-Response Relationship, Drug
Methyl Methanesulfonate antagonists & inhibitors
Methylcholanthrene toxicity
Microsomes, Liver enzymology
Mitomycin antagonists & inhibitors
Mutagenicity Tests
Salmonella typhimurium drug effects
Salmonella typhimurium genetics
Sodium Azide
Antimutagenic Agents pharmacology
Mutagens toxicity
Todralazine pharmacology
Subjects
Details
- Language :
- English
- ISSN :
- 0027-5107
- Volume :
- 324
- Issue :
- 3
- Database :
- MEDLINE
- Journal :
- Mutation research
- Publication Type :
- Academic Journal
- Accession number :
- 7517512
- Full Text :
- https://doi.org/10.1016/0165-7992(94)90057-4