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Is polyhydramnios in an ultrasonographically normal fetus an indication for genetic evaluation?
- Source :
-
American journal of obstetrics and gynecology [Am J Obstet Gynecol] 1995 Nov; Vol. 173 (5), pp. 1523-7. - Publication Year :
- 1995
-
Abstract
- Objective: Our purpose was to determine the frequency of fetal chromosomal anomalies in pregnancies complicated by polyhydramnios.<br />Study Design: Between Jan. 1, 1992, and July 31, 1993, an amniotic fluid index was measured prospectively in 2730 third-trimester pregnant women. Polyhydramnios was defined as an amniotic fluid index > or = 24 cm. A computer search identified all infants born with structural or chromosomal anomalies.<br />Results: Polyhydramnios was detected in 49 of 2730 women (1.7%). The incidence of chromosomal anomalies was two in 49 (4.1%) compared with three in 2681 (0.12%) among women with normal fluid (p < 0.05). Six of the 49 newborns had structural anomalies (12.2%), whereas 48 of 2681 (1.8%) structural anomalies occurred in the control group (p < 0.05). Among study patients both fetuses with chromosomal anomalies were growth retarded; four of the six structural anomalies were associated with an amniotic fluid index > 30 cm.<br />Conclusions: (1) Polyhydramnios is associated with an increased incidence of congenital fetal anomalies. (2) Growth-retarded fetuses with polyhydramnios warrant genetic evaluation. (3) A genetic study is not absolutely indicated for patients with polyhydramnios and a sonographically normal fetus.
- Subjects :
- Birth Weight
Chromosome Aberrations embryology
Chromosome Aberrations genetics
Chromosome Disorders
Congenital Abnormalities embryology
Congenital Abnormalities genetics
Female
Fetal Growth Retardation epidemiology
Genetic Diseases, Inborn genetics
Humans
Incidence
Infant, Newborn
Polyhydramnios diagnostic imaging
Polyhydramnios epidemiology
Pregnancy
Pregnancy Trimester, Third
Prospective Studies
Amniocentesis
Chromosome Aberrations epidemiology
Congenital Abnormalities epidemiology
Genetic Diseases, Inborn diagnosis
Polyhydramnios diagnosis
Ultrasonography, Prenatal
Subjects
Details
- Language :
- English
- ISSN :
- 0002-9378
- Volume :
- 173
- Issue :
- 5
- Database :
- MEDLINE
- Journal :
- American journal of obstetrics and gynecology
- Publication Type :
- Academic Journal
- Accession number :
- 7503195
- Full Text :
- https://doi.org/10.1016/0002-9378(95)90643-6