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Correlation between serological and mucosal inflammatory responses to Helicobacter pylori.
- Source :
-
Clinical and diagnostic laboratory immunology [Clin Diagn Lab Immunol] 1994 May; Vol. 1 (3), pp. 325-9. - Publication Year :
- 1994
-
Abstract
- In 82 patients who underwent gastroduodenoscopy, acute and chronic gastric mucosal inflammation was scored for severity, and systemic humoral immune responses to Helicobacter pylori antigens were assessed by enzyme-linked immunosorbent assays. On the basis of culture, gastric histology, and serologic evaluation, 33 patients were classified as H. pylori infected and 36 were classified as uninfected. Thirteen patients had negative cultures and stains but were seropositive and were analyzed separately from the other two groups. Specific serum immunoglobulin G (IgG) subclass responses to H. pylori whole-cell antigens and specific IgG responses to the 54-kDa heat shock protein homolog (Hp54K) and vacuolating cytotoxin were significantly greater in infected than in uninfected patients as were specific IgA responses to whole-cell antigens and cytotoxin (P < 0.001). Among the H. pylori-infected persons, serum IgG responses to Hp54K and to the vacuolating cytotoxin were correlated with acute mucosal inflammatory scores. In contrast, serum IgA responses to whole-cell sonicate and to vacuolating cytotoxin were inversely related to chronic inflammatory scores. By multivariant regression analysis, only specific serum IgG responses to Hp54K correlated with severity of inflammation (both acute and chronic; P < 0.001); these responses may be markers of inflammation or these antibodies could play a direct role in the pathogenesis of H. pylori-induced inflammation.
- Subjects :
- Antigens, Bacterial immunology
Bacterial Proteins immunology
Bacterial Toxins immunology
Biomarkers analysis
Chaperonin 60 immunology
Gastritis blood
Gastritis immunology
Gastritis pathology
Helicobacter Infections blood
Helicobacter Infections pathology
Humans
Middle Aged
Antibodies, Bacterial blood
Gastric Mucosa immunology
Gastric Mucosa pathology
Helicobacter Infections immunology
Helicobacter pylori immunology
Subjects
Details
- Language :
- English
- ISSN :
- 1071-412X
- Volume :
- 1
- Issue :
- 3
- Database :
- MEDLINE
- Journal :
- Clinical and diagnostic laboratory immunology
- Publication Type :
- Academic Journal
- Accession number :
- 7496970
- Full Text :
- https://doi.org/10.1128/cdli.1.3.325-329.1994