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GABAB receptors.
- Source :
-
Pharmacology & therapeutics [Pharmacol Ther] 1995; Vol. 67 (2), pp. 187-246. - Publication Year :
- 1995
-
Abstract
- GABAB receptors are a distinct subclass of receptors for the major inhibitory transmitter 4-aminobutanoic acid (GABA) that mediate depression of synaptic transmission and contribute to the inhibition controlling neuronal excitability. The development of specific agonists and antagonists for these receptors has led to a better understanding of their physiology and pharmacology, highlighting their diverse coupling to different intracellular effectors through Gi/G(o) proteins. This review emphasises our current knowledge of the neurophysiology and neurochemistry of GABAB receptors, including their heterogeneity, as well as the therapeutic potential of drugs acting at these sites.
- Subjects :
- Baclofen metabolism
Baclofen pharmacology
Binding, Competitive
Cations, Divalent pharmacology
Central Nervous System drug effects
Central Nervous System Diseases drug therapy
GABA Agonists metabolism
GABA Agonists therapeutic use
GABA Antagonists metabolism
GABA Antagonists therapeutic use
GTP-Binding Proteins metabolism
Humans
Neurophysiology
Radioligand Assay
Receptors, GABA-B chemistry
Receptors, GABA-B drug effects
Structure-Activity Relationship
Central Nervous System metabolism
GABA Agonists pharmacology
GABA Antagonists pharmacology
Receptors, GABA-B metabolism
Subjects
Details
- Language :
- English
- ISSN :
- 0163-7258
- Volume :
- 67
- Issue :
- 2
- Database :
- MEDLINE
- Journal :
- Pharmacology & therapeutics
- Publication Type :
- Academic Journal
- Accession number :
- 7494864
- Full Text :
- https://doi.org/10.1016/0163-7258(95)00016-a