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The Epstein-Barr virus nuclear antigen leader protein associates with hsp72/hsc73.
- Source :
-
Journal of virology [J Virol] 1995 Dec; Vol. 69 (12), pp. 8169-72. - Publication Year :
- 1995
-
Abstract
- Epstein-Barr virus nuclear antigen leader protein (EBNA-LP) is important for primary B-lymphocyte growth transformation. We now demonstrate that the W repeat-encoded domain of EBNA-LP significantly associates with proteins of the heat shock protein 70 family (hsp72/hsc73). hsp72/hsc73 may mediate the previously observed interaction between EBNA-LP and the retinoblastoma protein or p53.
- Subjects :
- Amino Acid Sequence
Antigens, Viral biosynthesis
Antigens, Viral isolation & purification
B-Lymphocytes immunology
B-Lymphocytes physiology
B-Lymphocytes virology
Cell Line
DNA-Binding Proteins biosynthesis
DNA-Binding Proteins isolation & purification
Electrophoresis, Polyacrylamide Gel
Epstein-Barr Virus Nuclear Antigens
Gene Expression
HSC70 Heat-Shock Proteins
HSP72 Heat-Shock Proteins
Heat-Shock Proteins chemistry
Heat-Shock Proteins isolation & purification
Humans
Lymphocyte Activation
Methionine metabolism
Molecular Sequence Data
Protein Binding
Recombinant Proteins biosynthesis
Recombinant Proteins isolation & purification
Recombinant Proteins metabolism
Retinoblastoma Protein metabolism
Trans-Activators isolation & purification
Trans-Activators metabolism
Tumor Suppressor Protein p53 metabolism
Antigens, Viral metabolism
DNA-Binding Proteins metabolism
HSP70 Heat-Shock Proteins
Heat-Shock Proteins metabolism
Subjects
Details
- Language :
- English
- ISSN :
- 0022-538X
- Volume :
- 69
- Issue :
- 12
- Database :
- MEDLINE
- Journal :
- Journal of virology
- Publication Type :
- Academic Journal
- Accession number :
- 7494344
- Full Text :
- https://doi.org/10.1128/JVI.69.12.8169-8172.1995