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The Epstein-Barr virus nuclear antigen leader protein associates with hsp72/hsc73.

Authors :
Mannick JB
Tong X
Hemnes A
Kieff E
Source :
Journal of virology [J Virol] 1995 Dec; Vol. 69 (12), pp. 8169-72.
Publication Year :
1995

Abstract

Epstein-Barr virus nuclear antigen leader protein (EBNA-LP) is important for primary B-lymphocyte growth transformation. We now demonstrate that the W repeat-encoded domain of EBNA-LP significantly associates with proteins of the heat shock protein 70 family (hsp72/hsc73). hsp72/hsc73 may mediate the previously observed interaction between EBNA-LP and the retinoblastoma protein or p53.

Details

Language :
English
ISSN :
0022-538X
Volume :
69
Issue :
12
Database :
MEDLINE
Journal :
Journal of virology
Publication Type :
Academic Journal
Accession number :
7494344
Full Text :
https://doi.org/10.1128/JVI.69.12.8169-8172.1995