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[Chemotherapy-induced hemolytic uremic syndrome. A complication to mitomycin treatment of breast carcinoma].
- Source :
-
Tidsskrift for den Norske laegeforening : tidsskrift for praktisk medicin, ny raekke [Tidsskr Nor Laegeforen] 1995 Nov 10; Vol. 115 (27), pp. 3371-3. - Publication Year :
- 1995
-
Abstract
- Mitomycin is a cytotoxic antibiotic that was first introduced into clinical use in 1958. Not until twenty years later was it recognised that haemolytic uremic syndrome could develop after treatment with mitomycin. It can be asked whether this condition was undiagnosed in previous years, since its frequency is now reported to be 4-15%. The disease appears to be dose-related, since it rarely occurs in patients who have received mitomycin < 30 mg/m2. No effective therapy has been established. We describe two patients with breast cancer in remission after treatment with mitomycin in combination with 5-fluorouracil. Both developed haemolytic uremic syndrome with fatal outcome.
- Subjects :
- Adult
Antibiotics, Antineoplastic administration & dosage
Antineoplastic Combined Chemotherapy Protocols administration & dosage
Antineoplastic Combined Chemotherapy Protocols adverse effects
Female
Fluorouracil administration & dosage
Hemolytic-Uremic Syndrome blood
Hemolytic-Uremic Syndrome pathology
Humans
Middle Aged
Mitomycins administration & dosage
Antibiotics, Antineoplastic adverse effects
Breast Neoplasms drug therapy
Hemolytic-Uremic Syndrome chemically induced
Mitomycins adverse effects
Subjects
Details
- Language :
- Norwegian
- ISSN :
- 0029-2001
- Volume :
- 115
- Issue :
- 27
- Database :
- MEDLINE
- Journal :
- Tidsskrift for den Norske laegeforening : tidsskrift for praktisk medicin, ny raekke
- Publication Type :
- Academic Journal
- Accession number :
- 7491579