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MMR vaccination, measles epidemiology and sero-surveillance in the Republic of Ireland.
- Source :
-
Vaccine [Vaccine] 1995 Apr; Vol. 13 (6), pp. 533-7. - Publication Year :
- 1995
-
Abstract
- Objective: Following the introduction of a national measles and subsequent MMR vaccination programme, to determine the susceptibility of 3-14-year-old children to measles, mumps and rubella and to relate the results to the epidemiology of measles and the need for vaccination policy changes.<br />Design: Cross-sectional sero-survey and trends in measles notifications and mortality.<br />Setting: Paediatric hospital outpatient departments in Dublin.<br />Subjects: Sera were collected from 837 children attending the clinics in 1991 and 1992.<br />Results: The prevalence of antibodies in children aged 3-6, 7-10 and 11-14 years was 84, 83 and 95% for measles; 48, 60 and 65% for mumps; and 78, 63 and 74% for rubella, respectively. The prevalence of mumps antibodies may be underestimated. Ninety-six per cent of girls aged 13-14 years had rubella antibodies. A widespread outbreak of measles occurred in 1993. Over recent years, an increasing proportion of measles notifications were in older children.<br />Conclusion: Given sub-optimal uptake of MMR vaccine, outbreaks of infection in pre- and primary school children are inevitable. In such circumstances, a 2-shot MMR vaccine programme with high uptake is essential to prevent a shift of disease into older age groups.
- Subjects :
- Adolescent
Age Factors
Antibodies, Viral blood
Child
Child, Preschool
Cross-Sectional Studies
Disease Susceptibility
Female
Humans
Immunoglobulin G blood
Immunoglobulin M blood
Ireland epidemiology
Male
Measles prevention & control
Measles Vaccine pharmacokinetics
Measles-Mumps-Rubella Vaccine
Mumps epidemiology
Mumps prevention & control
Mumps Vaccine pharmacokinetics
Rubella epidemiology
Rubella prevention & control
Rubella Vaccine pharmacokinetics
Seroepidemiologic Studies
Vaccines, Combined pharmacokinetics
Vaccines, Combined therapeutic use
Measles epidemiology
Measles Vaccine therapeutic use
Mumps Vaccine therapeutic use
Rubella Vaccine therapeutic use
Vaccination
Subjects
Details
- Language :
- English
- ISSN :
- 0264-410X
- Volume :
- 13
- Issue :
- 6
- Database :
- MEDLINE
- Journal :
- Vaccine
- Publication Type :
- Academic Journal
- Accession number :
- 7483773
- Full Text :
- https://doi.org/10.1016/0264-410x(94)00021-e