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An alternative pathway for signal flow from rod photoreceptors to ganglion cells in mammalian retina.
- Source :
-
Proceedings of the National Academy of Sciences of the United States of America [Proc Natl Acad Sci U S A] 1995 Nov 07; Vol. 92 (23), pp. 10658-62. - Publication Year :
- 1995
-
Abstract
- Rod signals in the mammalian retina are thought to reach ganglion cells over the circuit rod-->rod depolarizing bipolar cell-->AII amacrine cell-->cone bipolar cells-->ganglion cells. A possible alternative pathway involves gap junctions linking the rods and cones, the circuit being rod-->cone-->cone bipolar cells-->ganglion cells. It is not clear whether this second pathway indeed relays rod signals to ganglion cells. We studied signal flow in the isolated rabbit retina with a multielectrode array, which allows the activity of many identified ganglion cells to be observed simultaneously while the preparation is stimulated with light and/or exposed to drugs. When transmission between rods and rod depolarizing bipolar cells was blocked by the glutamate agonist 2-amino-4-phosphonobutyric acid (APB), rod input to all On-center and briskly responding Off-center ganglion cells was dramatically reduced as expected. Off responses persisted, however, in Off-center sluggish and On-Off direction-selective ganglion cells. Presumably these responses were generated by the alternative pathway involving rod-cone junctions. This APB-resistant pathway may carry the major rod input to Off-center sluggish and On-Off direction-selective ganglion cells.
- Subjects :
- Aminobutyrates pharmacology
Animals
Dose-Response Relationship, Radiation
Electrophysiology
Excitatory Amino Acid Agonists pharmacology
In Vitro Techniques
Light
Models, Biological
Rabbits
Retinal Rod Photoreceptor Cells drug effects
Retinal Rod Photoreceptor Cells radiation effects
Vision, Ocular physiology
Cell Communication
Retinal Ganglion Cells physiology
Retinal Rod Photoreceptor Cells physiology
Subjects
Details
- Language :
- English
- ISSN :
- 0027-8424
- Volume :
- 92
- Issue :
- 23
- Database :
- MEDLINE
- Journal :
- Proceedings of the National Academy of Sciences of the United States of America
- Publication Type :
- Academic Journal
- Accession number :
- 7479860
- Full Text :
- https://doi.org/10.1073/pnas.92.23.10658