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Hormonal modulation of gap junctions in rat ovarian follicles.
- Source :
-
Cell and tissue research [Cell Tissue Res] 1981; Vol. 214 (1), pp. 181-93. - Publication Year :
- 1981
-
Abstract
- Homocellular gap junctions between granulosa cells and between theca interna cells, and heterocellular gap junctions between granulosa cells and oocytes persist in rat ovarian follicles for as long as 90 days following hypophysectomy. Gonadotrophic and/or steroid hormones are therefore not required for the maintenance of gap junctions between these cells during early follicular growth. However, replacement therapy with estrogen and human chorionic gonadotrophin results in amplification of gap junctions in granulosa and theca interna cells respectively. Within 24h following hormonal stimulation, growth of gap junctions is characterized by the appearance of formation plaques as observed in freeze-fracture replicas and by the association of microfilamentous material located subadjacent to gap junction membrane observable in thin-sectioned cells.
- Subjects :
- Animals
Female
Granulosa Cells drug effects
Hypophysectomy
Oocytes ultrastructure
Progesterone pharmacology
Rats
Theca Cells drug effects
Chorionic Gonadotropin pharmacology
Estradiol pharmacology
Granulosa Cells ultrastructure
Intercellular Junctions ultrastructure
Theca Cells ultrastructure
Subjects
Details
- Language :
- English
- ISSN :
- 0302-766X
- Volume :
- 214
- Issue :
- 1
- Database :
- MEDLINE
- Journal :
- Cell and tissue research
- Publication Type :
- Academic Journal
- Accession number :
- 7471172
- Full Text :
- https://doi.org/10.1007/BF00235155