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Suppression of threatened premature labor by administration of cortisol and 17 alpha-hydroxyprogesterone caproate: a comparison with ritodrine.
- Source :
-
American journal of obstetrics and gynecology [Am J Obstet Gynecol] 1980 Oct 15; Vol. 138 (4), pp. 404-8. - Publication Year :
- 1980
-
Abstract
- A shift in progesterone-to-estradiol balance to estradiol dominance is assumed to be a prerequisite for regular uterine contractions. To antagonize this effect in premature labor 24 consecutive women were treated with intravenous cortisol for 3 days and with weekly intramuscular injections of 17 alpha-hydroxyprogesterone caproate (17 OHP-C). Twenty-four similar patients treated with ritodrine served as a reference group. The delivery was postponed by at least 1 week in 21 patients (87.5%) in the steroid treatment group and in 18 patients (75%) in the ritodrine group. The premature labor lasted for 5.1 +/- 0.4 hours (mean +/- SEM) with steroid therapy and for 2.2 +/- 0.3 hours with ritodrine. In singleton pregnancies the gestational length and birth weight of the newborn infants were greater in the steroid treatment group (N = 23, 39.1 +/- 0.3 weeks, 3,460 +/- 119 gm) than in the ritodrine group (N = 24, 37.7 +/- 0.4 weeks, 3,106 +/- 118 gm). Steroid treatment suppressed serum estradiol concentrations (maximally by 60%) and, to a lesser extent, testosterone, estriol, and progresterone levels (maximally by 30%).
- Subjects :
- 17 alpha-Hydroxyprogesterone Caproate
Estradiol blood
Estriol blood
Female
Humans
Pregnancy
Progesterone blood
Testosterone blood
Estrogen Antagonists therapeutic use
Hydrocortisone therapeutic use
Hydroxyprogesterones therapeutic use
Obstetric Labor, Premature prevention & control
Propanolamines therapeutic use
Ritodrine therapeutic use
Subjects
Details
- Language :
- English
- ISSN :
- 0002-9378
- Volume :
- 138
- Issue :
- 4
- Database :
- MEDLINE
- Journal :
- American journal of obstetrics and gynecology
- Publication Type :
- Academic Journal
- Accession number :
- 7424996
- Full Text :
- https://doi.org/10.1016/0002-9378(80)90137-4