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[Numerical analysis of myocardial action potentials].

Authors :
Nilius B
Source :
Acta biologica et medica Germanica [Acta Biol Med Ger] 1980; Vol. 39 (2-3), pp. 243-54.
Publication Year :
1980

Abstract

A numerical method is described suitable to reconstruct the repolarization phase of the action potential measured from the mammalian atrial myocardium. The method allows an estimation of the current-voltage relationship of a time-independent potassium outward current and a voltage- and time-dependent calcium current, an inactivation term of the calcium current and an estimation of the calcium and potassium amounts transported during the action potential. The numerical evaluation needs some pairs of voltage-time values obtained from the measured action potentials and the first time derivative of the action potential. An example of the method's usefulness is demonstrated. The described method is suitable to reconstruct the late repolarization phase of the atrial action potentials sufficiently.

Details

Language :
German
ISSN :
0001-5318
Volume :
39
Issue :
2-3
Database :
MEDLINE
Journal :
Acta biologica et medica Germanica
Publication Type :
Academic Journal
Accession number :
7424343