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Tumoricidal response induced by cytosine arabinoside after plasma perfusion over protein A.
- Source :
-
Science (New York, N.Y.) [Science] 1980 Sep 12; Vol. 209 (4462), pp. 1257-9. - Publication Year :
- 1980
-
Abstract
- In dogs with spontaneous mammary adenocarcinomas, a single nontoxic infusion of cytosine arabinoside after extracorporeal perfusion of plasms over immobilized protein A resulted in a necrotizing response rapid in onset and specific for tumorous tissue. Gross tumoricidal reactions 12 hours after this combined treatment exceeded the algebraic sum of responses to cytosine arabinoside and protein A perfusion treatments alone in the same dogs, implying a synergistic effect between the two. The magnitude, rapidity, and specificity of the tumoricidal response after the combined treatment suggests that it may be an effective chemimmunotherapeutic approach to breast adenocarcinoma.
- Subjects :
- Animals
Antibodies, Neoplasm
Cytarabine therapeutic use
Dogs
Female
Immunotherapy
Mammary Neoplasms, Experimental immunology
Mammary Neoplasms, Experimental pathology
Necrosis
Perfusion
Staphylococcal Protein A immunology
Staphylococcus aureus immunology
Adenocarcinoma therapy
Cytarabine administration & dosage
Mammary Neoplasms, Experimental therapy
Staphylococcal Protein A therapeutic use
Subjects
Details
- Language :
- English
- ISSN :
- 0036-8075
- Volume :
- 209
- Issue :
- 4462
- Database :
- MEDLINE
- Journal :
- Science (New York, N.Y.)
- Publication Type :
- Academic Journal
- Accession number :
- 7403885
- Full Text :
- https://doi.org/10.1126/science.7403885