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Sixty-five years of sympathetic ophthalmia. A clinicopathologic review of 105 cases (1913--1978).
- Source :
-
Ophthalmology [Ophthalmology] 1980 Feb; Vol. 87 (2), pp. 109-21. - Publication Year :
- 1980
-
Abstract
- A retrospective clinicopathologic review of 105 cases of sympathetic ophthalmia showed histologic features of prognostic significance and evaluated the role of therapy. Classic descriptions omit retinal changes, but 58.0% of our cases had retinal detachment and 42.2% showed intraretinal inflammation. The optic nerve and/or meninges were inflamed in 51%. Optic atrophy was seen in 54.4%. Plasma cells are said to be characteristically absent, but 65.0% of steroid-treated and 85.7% of cases before the steroid era showed plasma cell infiltration. Severity of inflammation pathologically correlated with final visual outcome, and corticosteroid therapy changed both the character and severity of inflammation. Early enucleation of the exciting eye after onset of symptoms in the fellow eye was found to improve visual prognosis. Electron microscopy performed on fresh tissue and choroidal cell cultures revealed no viral particles, and viral and mycoplasma cultures all proved negative.
- Subjects :
- Adolescent
Adrenal Cortex Hormones therapeutic use
Adult
Aged
Child
Child, Preschool
Female
Humans
Infant
Infant, Newborn
Male
Middle Aged
Ophthalmia, Sympathetic complications
Ophthalmia, Sympathetic therapy
Ophthalmologic Surgical Procedures
Optic Atrophy etiology
Plasma Cells pathology
Prognosis
Visual Acuity
Eye Injuries complications
Ophthalmia, Sympathetic pathology
Retinal Detachment etiology
Subjects
Details
- Language :
- English
- ISSN :
- 0161-6420
- Volume :
- 87
- Issue :
- 2
- Database :
- MEDLINE
- Journal :
- Ophthalmology
- Publication Type :
- Academic Journal
- Accession number :
- 7383540
- Full Text :
- https://doi.org/10.1016/s0161-6420(80)35270-6