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Povidone panniculitis. Polyvinylpyrrolidone panniculitis.
- Source :
-
Archives of dermatology [Arch Dermatol] 1980 Jun; Vol. 116 (6), pp. 704-6. - Publication Year :
- 1980
-
Abstract
- Multiple subcutaneous nodules and recurrent flu-like episodes developed in a 60-year-old woman after she had received local intramuscular injections of procaine povidone for a seven-year period. A skin biopsy specimen showed distinctive gray-blue material in the histiocytes in sections stained with hematoxylin-eosin. Povidone is an inert substance that may accumulate in multiple organs, including the skin. Its presence can be verified by its affinity for special stains or by spectrophotometric analysis. In our patient, ultrastructural study showed amorphous inrahistiocytic deposits in the tissues. -revious reports have indicated that this substance may eventually accumulate in noninjected skin sites and may lead to pulmonary and arthritic symptoms in some patients, but no other patients, to our knowledge, have had complications associated with fever.
- Subjects :
- Female
Histiocytes ultrastructure
Humans
Injections, Intramuscular
Middle Aged
Povidone administration & dosage
Procaine administration & dosage
Procaine adverse effects
Skin pathology
Skin ultrastructure
Panniculitis, Nodular Nonsuppurative chemically induced
Panniculitis, Nodular Nonsuppurative pathology
Povidone adverse effects
Subjects
Details
- Language :
- English
- ISSN :
- 0003-987X
- Volume :
- 116
- Issue :
- 6
- Database :
- MEDLINE
- Journal :
- Archives of dermatology
- Publication Type :
- Academic Journal
- Accession number :
- 7377808