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Renal disease in familial dysautonomia.
- Source :
-
Kidney international [Kidney Int] 1980 Jan; Vol. 17 (1), pp. 102-12. - Publication Year :
- 1980
-
Abstract
- A study of renal disease in familial dysautonomia identified excess glomerulosclerosis in 10 or 13 autopsied and biopsied patients. Sympathetic nerve terminals could not be found on renal vessels in biopsied tissue; they were invariably demonstrable in controls. Altered renovascular responsivity to systemic hypotension in familial dysautonomia may lead to ischemia and subsequent sclerosis of glomeruli. Review of 79 living outpatients showed that clinically overt renal disease was rare in familial dysautonomia. Nevertheless, frequent observations of elevations of serum creatinine concentrations (32% of patients) and blood urea concentrations (76% of patients) indicated a high prevalence of abnormality. An association was found between hypotension and renal dysfunction.
- Subjects :
- Adolescent
Adult
Autopsy
Biopsy
Blood Pressure
Blood Urea Nitrogen
Child
Child, Preschool
Creatinine blood
Dysautonomia, Familial pathology
Female
Humans
Infant
Infant, Newborn
Kidney Diseases pathology
Kidney Glomerulus pathology
Male
Nephrosclerosis etiology
Nephrosclerosis pathology
Dysautonomia, Familial complications
Kidney Diseases etiology
Subjects
Details
- Language :
- English
- ISSN :
- 0085-2538
- Volume :
- 17
- Issue :
- 1
- Database :
- MEDLINE
- Journal :
- Kidney international
- Publication Type :
- Academic Journal
- Accession number :
- 7374014
- Full Text :
- https://doi.org/10.1038/ki.1980.12