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Griseorubins, a new family of antibiotics with antimicrobial and antitumor activity. II. Biological properties and antitumor activity of the antibiotic complex griseorubin.
- Source :
-
The Journal of antibiotics [J Antibiot (Tokyo)] 1980 Jan; Vol. 33 (1), pp. 9-12. - Publication Year :
- 1980
-
Abstract
- The antibiotic complex griseorubin has antimicrobial activity against Gram-positive as well as -negative bacteria, mycobacteria, mycoplasma and protozoa in vitro but it is not active against yeast and fungi. Tests with transplantable rodent tumors indicate that griseorubin is inhibitory to the growth of lymphatic leukemia L1210 in mice and Zajdela ascites hepatoma in rats. The acute LD50 of griseorubin in mice is 50 mg/kg of body weight when given intraperitoneally. Attempts to potentiate the antitumor activity by complexing with DNA proved to be unsuccessful.
- Subjects :
- Animals
Antibiotics, Antineoplastic analysis
Bacteria drug effects
Cell Survival drug effects
DNA analysis
Female
Leukemia L1210 drug therapy
Male
Mice
Mice, Inbred Strains
Mycoplasma drug effects
Neoplasms, Experimental drug therapy
Trypanosoma drug effects
Antibiotics, Antineoplastic pharmacology
Subjects
Details
- Language :
- English
- ISSN :
- 0021-8820
- Volume :
- 33
- Issue :
- 1
- Database :
- MEDLINE
- Journal :
- The Journal of antibiotics
- Publication Type :
- Academic Journal
- Accession number :
- 7372557
- Full Text :
- https://doi.org/10.7164/antibiotics.33.9