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Histamine pharmacology in airway smooth muscle from a canine model of asthma.
- Source :
-
The Journal of pharmacology and experimental therapeutics [J Pharmacol Exp Ther] 1980 Apr; Vol. 213 (1), pp. 150-5. - Publication Year :
- 1980
-
Abstract
- Tracheal smooth muscle (TSM) from an ovalbumin sensitized canine model of allergic asthma showed hypersensitivity and hyper-reactivity to histamine (H) when compared to that from littermate controls in vitro. Mepyramine abolished H responses in TSM of both groups; it also abolished the allergic response to obalbumin of TSM from sensitized dogs. The H2 receptor agonist, 4-methyl histamine (4-MH) caused small dose-related decreases in H contractures but had no effect on carbachol- or K+-induced tension. Metiamide, an H2 antagonist, did not enhance the H contracture, suggesting the 4-MH may not be exerting a relaxant effect since H2 receptors were absent. The maximum H-induced isometric tension was potentiated when the sensitized and control muscle strips were pre-equilibrated with 4-MH. These observations are consistent with the presence in canine TSM of H1 but not relaxant H2 receptors, the release of endogenous H to the tissue during the antigen-antibody reaction, and the competition of H and 4-MH for the H1 receptors. Experiments with specific blockers also indicated that in this model the only transmitter found in the ovalbumin-induced allergic bronchospasm was histamine.
- Subjects :
- Anaphylaxis physiopathology
Animals
Asthma immunology
Dogs
In Vitro Techniques
Methylhistamines pharmacology
Metiamide pharmacology
Muscle Contraction drug effects
Muscle, Smooth drug effects
Ovalbumin immunology
Pyrilamine pharmacology
Receptors, Histamine H2 drug effects
Trachea drug effects
Airway Resistance drug effects
Asthma physiopathology
Histamine pharmacology
Subjects
Details
- Language :
- English
- ISSN :
- 0022-3565
- Volume :
- 213
- Issue :
- 1
- Database :
- MEDLINE
- Journal :
- The Journal of pharmacology and experimental therapeutics
- Publication Type :
- Academic Journal
- Accession number :
- 7359363