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Studies on visceral Leishmania tropica infection in BALB/c mice. I. Clinical features and cellular changes.

Authors :
Djoko-Tamnou J
Leclerc C
Modabber F
Chedid L
Source :
Clinical and experimental immunology [Clin Exp Immunol] 1981 Dec; Vol. 46 (3), pp. 493-8.
Publication Year :
1981

Abstract

The visceral and lethal infection produced in BALB/c mice by Leishmania tropica (major) is accompanied by splenomegaly, anaemia and reversal of albumin-to-globulin ratio. The percentages of both B and T cells are decreased in the spleen. The spleen and lymph nodes become populated with large Ig-, Thy 1.2- 'null' cells. The similarity of some of these parameters with those produced in human kala-azar is discussed.

Details

Language :
English
ISSN :
0009-9104
Volume :
46
Issue :
3
Database :
MEDLINE
Journal :
Clinical and experimental immunology
Publication Type :
Academic Journal
Accession number :
7337976