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Urea cycle and protein content in leucocytes from normal persons and uraemics.
- Source :
-
Proceedings of the European Dialysis and Transplant Association. European Dialysis and Transplant Association [Proc Eur Dial Transplant Assoc] 1981; Vol. 18, pp. 638-41. - Publication Year :
- 1981
-
Abstract
- It was found experimentally that the activity of the urea-cycle enzymes in the leucocytes of uraemic rats was parallel to that in their liver. Conclusions as to the activity of the urea-cycle enzymes in the liver can thus be drawn from the urea-cycle enzyme activity in the leucocytes. Investigation of the urea-cycle enzyme in the leucocytes of patients with renal insufficiency, in the pre-dialytic and dialytic states, showed that in both groups the ornithine carbamoyl transferase and the argininosuccinate lyase activity was lower in both groups of patients than in normal persons. The dialysis patients show higher argininosuccinate synthetase activity. In both groups of patients the protein content of the leucocytes is markedly lowered.
- Subjects :
- Animals
Arginase blood
Argininosuccinate Lyase blood
Argininosuccinate Synthase blood
Carbamoyl-Phosphate Synthase (Ammonia) blood
Carbamoyl-Phosphate Synthase (Glutamine-Hydrolyzing) blood
Humans
Leukocytes enzymology
Ornithine Carbamoyltransferase blood
Rats
Rats, Inbred Strains
Renal Dialysis
Urea metabolism
Uremia enzymology
Uremia therapy
Blood Proteins analysis
Leukocytes metabolism
Uremia blood
Subjects
Details
- Language :
- English
- ISSN :
- 0071-2736
- Volume :
- 18
- Database :
- MEDLINE
- Journal :
- Proceedings of the European Dialysis and Transplant Association. European Dialysis and Transplant Association
- Publication Type :
- Academic Journal
- Accession number :
- 7329991