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Carcinogenicity of 4-chloro-o-phenylenediamine, 4-chloro-m-phenylenediamine, and 2-chloro-p-phenylenediamine in Fischer 344 rats and B6C3F1 mice.
- Source :
-
Carcinogenesis [Carcinogenesis] 1980 Jun; Vol. 1 (6), pp. 495-9. - Publication Year :
- 1980
-
Abstract
- In both male and female Fischer rats, feeding 4-chloro-o-phenylenediamine at 0.5 or 1% in the diet led to a significant increase in hyperplasia, papilloma and carcinoma of the urinary bladder. Neoplastic nodules of the liver and squamous cell papillomas of the stomach were also increased slight. Similar levels of this compound in male and female B6C3F1 mice increased significantly the incidence of hepatocellular adenomas and carcinomas. 4-Chloro-m-phenylenediamine at 0.2 or 0.4% in the diet led to a significant elevation in the incidence of adrenal pheochromocytoma in male rats. At 1 or 2% levels it caused hepatocellular adenoma in female mice. Although the analog, 2-chloro-p-phenylenediamine increased transitional cell hyperplasia of the kidney in both male and female rats, it had no significant neoplastic effect at the 0.15 or 0.3% levels fed.
- Subjects :
- Animals
Carcinoma, Transitional Cell chemically induced
Epithelium drug effects
Female
Male
Mice
Neoplasms, Experimental chemically induced
Rats
Rats, Inbred F344
Structure-Activity Relationship
Urologic Neoplasms chemically induced
Carcinogens
Coloring Agents toxicity
Phenylenediamines toxicity
Subjects
Details
- Language :
- English
- ISSN :
- 0143-3334
- Volume :
- 1
- Issue :
- 6
- Database :
- MEDLINE
- Journal :
- Carcinogenesis
- Publication Type :
- Academic Journal
- Accession number :
- 7273282
- Full Text :
- https://doi.org/10.1093/carcin/1.6.495