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Phase II trial of iv 6-thioguanine in advanced colorectal carcinoma.
- Source :
-
Cancer treatment reports [Cancer Treat Rep] 1981 Sep-Oct; Vol. 65 (9-10), pp. 909-10. - Publication Year :
- 1981
-
Abstract
- Oral 6-thioguanine (6-TG) is an S-phase antimetabolite with significant activity against acute leukemia. Preliminary reports of activity of iv 6-TG indicated significant activity against advanced colorectal cancer. We conducted a phase II study of iv 6-TG in 29 patients with advanced measurable colorectal cancer. Only one transient partial response occurred. Toxic effects included mild myelosuppression, nausea, vomiting, and minor ECG changes. We discourage further use of iv 6-TG in the dose and schedule we used to treat advanced colorectal cancer.
- Subjects :
- Aged
Drug Evaluation
Female
Heart drug effects
Heart physiopathology
Humans
Injections, Intravenous
Middle Aged
Myeloproliferative Disorders chemically induced
Nausea chemically induced
Thioguanine adverse effects
Vomiting chemically induced
Colonic Neoplasms drug therapy
Rectal Neoplasms drug therapy
Thioguanine therapeutic use
Subjects
Details
- Language :
- English
- ISSN :
- 0361-5960
- Volume :
- 65
- Issue :
- 9-10
- Database :
- MEDLINE
- Journal :
- Cancer treatment reports
- Publication Type :
- Academic Journal
- Accession number :
- 7273027