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A study of potential skin atrophy following topical application of weak corticosteroids.
- Source :
-
Current medical research and opinion [Curr Med Res Opin] 1981; Vol. 7 (7), pp. 463-70. - Publication Year :
- 1981
-
Abstract
- A double-blind, half-side comparative dermal atrophy study of fluocortin butylester 0.75% clobetasone butyrate 0.05%, hydrocortisone acetate 1% and placebo creams was carried out in 29 healthy human male volunteers. Skin thickness was measured by a modified radiographic technique before and after an 8-week application period of the test preparations. Significant skin thinning occurred in 3 of the 10 subjects treated with clobetasone butyrate and atrophy of marginal significance in 1 of the 29 subjects treated with fluocortin butylester. The results suggest that, compared with other fluorinated topical steroids, fluocortin butylester 0.75% is unlikely to produce significant dermal atrophy when used in the short and medium term.
- Subjects :
- Administration, Topical
Adolescent
Adult
Anti-Inflammatory Agents adverse effects
Atrophy chemically induced
Clobetasol adverse effects
Clobetasol analogs & derivatives
Double-Blind Method
Fluocortolone adverse effects
Fluocortolone analogs & derivatives
Humans
Hydrocortisone adverse effects
Hydrocortisone analogs & derivatives
Male
Middle Aged
Placebos
Adrenal Cortex Hormones adverse effects
Skin pathology
Subjects
Details
- Language :
- English
- ISSN :
- 0300-7995
- Volume :
- 7
- Issue :
- 7
- Database :
- MEDLINE
- Journal :
- Current medical research and opinion
- Publication Type :
- Academic Journal
- Accession number :
- 7261664
- Full Text :
- https://doi.org/10.1185/03007998109114285