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Further evidence for an acetylator phenotype difference in the metabolism of hydralazine in man.
- Source :
-
British journal of clinical pharmacology [Br J Clin Pharmacol] 1981 Apr; Vol. 11 (4), pp. 345-51. - Publication Year :
- 1981
-
Abstract
- 1 The 0-24 h urine from hypertensive patients treated with hydralazine (100 mg twice daily) has been analysed by gas chromatography and high pressure liquid chromatography. 2 4-N-Acetylhydrazinophthalazine-1-one (NAcHPZ), s-triazolo [3, 4-a] phthalazine (TP), phthalazinone (PZ) and hydralazine (free, H; acid-labile hydrazones, HH) were detected and assayed. 3 The results indicate that slow acetylators excrete less NAcHPZ and TP than rapid acetylators but more PZ and HH. 4 Free hydralazine was present in low levels and was only detected in some urine samples. 5 The ratios of the metabolites NAcHPZ/HH; TP/HH; NAcHPZ/PZ and PZ/TP are different in the two acetylator phenotypes. 6 It is possible the ratio PZ/TP may be used for determination of acetylator phenotype. 7 It is concluded that hydralazine metabolism is dependent on the acetylator phenotype.
Details
- Language :
- English
- ISSN :
- 0306-5251
- Volume :
- 11
- Issue :
- 4
- Database :
- MEDLINE
- Journal :
- British journal of clinical pharmacology
- Publication Type :
- Academic Journal
- Accession number :
- 7259927
- Full Text :
- https://doi.org/10.1111/j.1365-2125.1981.tb01131.x