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Toxic effects of violamycin Bi, carminomycin and daunorubicin on the myocardium of rabbits.
- Source :
-
Acta pharmacologica et toxicologica [Acta Pharmacol Toxicol (Copenh)] 1981 Feb; Vol. 48 (2), pp. 87-94. - Publication Year :
- 1981
-
Abstract
- Cardiac toxicity of the new anthracycline antitumour antibiotics violamycin BI (V) and carminomycin (C) was studied in comparison with daunorubicin (D). Rabbits were intravenously given total doses of 0.1-1.5 mg/kg V or C, and 0.64-18 mg/kg D, respectively, twice weekly for one month. When examined two to six days, two and four weeks, respectively, after the last drug administration the gross findings consisted of hydropericard, hydrothorax and ascites in some animals. Histologically, loss of striation and focal necrosis of cardiac muscle cells and subsequently chronic inflammatory reactions and/or proliferation of mesenchyma cells were mostly found. These alterations were somewhat more pronounced in rabbits treated with V than in animals received D or C. At equitoxic doses of the antibiotics tested the ultrastructural lesion in the myocardial cells were altogether less marked after treatment with D than with C or V.
- Subjects :
- Aminoglycosides administration & dosage
Aminoglycosides toxicity
Animals
Carubicin administration & dosage
Daunorubicin administration & dosage
Dose-Response Relationship, Drug
Female
Hydrothorax chemically induced
Male
Myocardium pathology
Pericardium drug effects
Pericardium pathology
Rabbits
Anti-Bacterial Agents
Carubicin toxicity
Daunorubicin analogs & derivatives
Daunorubicin toxicity
Heart drug effects
Subjects
Details
- Language :
- English
- ISSN :
- 0001-6683
- Volume :
- 48
- Issue :
- 2
- Database :
- MEDLINE
- Journal :
- Acta pharmacologica et toxicologica
- Publication Type :
- Academic Journal
- Accession number :
- 7257833
- Full Text :
- https://doi.org/10.1111/j.1600-0773.1981.tb01593.x