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Identification of two Thormählen-positive compounds from melanotic urine by gas chromatography-mass spectrometry.
- Source :
-
Journal of chromatography [J Chromatogr] 1981 Mar 13; Vol. 222 (3), pp. 329-36. - Publication Year :
- 1981
-
Abstract
- The isolation of two Thormählen-positive compounds from the urine of a patient with malignant melanoma and the elucidation of their structure by gas chromatography-mass spectometry is described. The compounds were isolated using a poly-N-vinylpyrrolidone column and separated by preparative thin-layer chromatography. After elution they were analyzed by gas chromatography and gas chromatography-mass spectrometry as their trimethylsilyl derivatives and after hydrolysis also as their tert.-butyldimethylsilyl derivatives. The results showed the main Thormählen-positive compound A to be the glucuronide of 5-hydroxy-6-methoxyindole, whereas the minor compound AX appeared to be the glucuronide of its isomer 6-hydroxy-5-methoxyindole.
Details
- Language :
- English
- Volume :
- 222
- Issue :
- 3
- Database :
- MEDLINE
- Journal :
- Journal of chromatography
- Publication Type :
- Academic Journal
- Accession number :
- 7228942
- Full Text :
- https://doi.org/10.1016/s0378-4347(00)84132-8