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Loss of membrane excitability after herpes simplex virus infection in tissue-cultured nerve cells from adult mammals.
- Source :
-
Brain research [Brain Res] 1981 Apr 27; Vol. 211 (1), pp. 235-41. - Publication Year :
- 1981
-
Abstract
- Dorsal root ganglion cells of adult guinea-pigs in vitro were inoculated with herpes simplex virus (HSV). Intracellular recording with a glass microelectrode revealed that HSV-infection caused a marked decrease in membrane excitability of the nerve cells within 24 h, which could be explained as a decrease in Na+ channel activity in the plasma membrane; while changes in other physiological properties (resting membrane potential, membrane resistance and capacitance) remain small. Viral antigens were detected in only 10-15% of the HSV-infected nerve cells. These indicate that the loss of the membrane excitability occurs much earlier than any other change in the HSV-infected nerve cells.
Details
- Language :
- English
- ISSN :
- 0006-8993
- Volume :
- 211
- Issue :
- 1
- Database :
- MEDLINE
- Journal :
- Brain research
- Publication Type :
- Academic Journal
- Accession number :
- 7225841
- Full Text :
- https://doi.org/10.1016/0006-8993(81)90090-1