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Irreversible thermic shock in rats: methods and results of a standardized shock model.
- Source :
-
The Journal of international medical research [J Int Med Res] 1981; Vol. 9 (1), pp. 21-30. - Publication Year :
- 1981
-
Abstract
- A standardized model for thermic shock in rats is described: 30% of the body surface, i.e. an oval-shaped area from neck to tail and limited by the connecting line between front and back limb, is exposed to 70 degrees C water for 180 seconds. The mean survival time was 2.63 +/- 1.22 hours. Immediately after burn injury, thermic shock developed with decline of respiratory and heart frequency and there was a decrease of arterial blood pressure in the first hour after shock had been induced. Severe decline in pO2 in arterial blood and in ATP occurred 30 minutes after injury and a similar increase in blood glucose, lactate, pCO2 and arterial pH was noted. Pathological changes were demonstrable in liver, kidneys, spleen, heart, lung, small intestine and pancreas: disseminated intravascular coagulation and capillary stasis were predominant in all organs; in addition different changes in organs are described (cell injury, oedema etc. in lung, liver, kidney and pancreas).
Details
- Language :
- English
- ISSN :
- 0300-0605
- Volume :
- 9
- Issue :
- 1
- Database :
- MEDLINE
- Journal :
- The Journal of international medical research
- Publication Type :
- Academic Journal
- Accession number :
- 7202828
- Full Text :
- https://doi.org/10.1177/030006058100900105