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Dihydroxytryptamines as tools to study the neurobiology of serotonin.
- Source :
-
Brain research bulletin [Brain Res Bull] 1982 Jul-Dec; Vol. 9 (1-6), pp. 131-50. - Publication Year :
- 1982
-
Abstract
- The neurotoxins 5,6- and 5,7-dihydroxytryptamine are accepted tools for "chemical degeneration" of serotonergic (5-HT) axons in the CNS (for reviews, see [11, 12, 15, 20] ). Optimum application of these substances requires knowledge of their chemical properties, disposition in the biophase and mechanism of action. Current knowledge and concepts on this issue are described and results of recent studies utilizing 5,7-DHT uptake as a tool for localizing 5-HT neurons neuroanatomically are reviewed.
- Subjects :
- 5,6-Dihydroxytryptamine metabolism
5,6-Dihydroxytryptamine toxicity
5,7-Dihydroxytryptamine metabolism
5,7-Dihydroxytryptamine toxicity
Animals
Autoradiography
Axons drug effects
Brain drug effects
Brain Stem metabolism
Dominance, Cerebral drug effects
Monoamine Oxidase metabolism
Nerve Degeneration drug effects
Neurons metabolism
Raphe Nuclei metabolism
Rats
Brain metabolism
Dihydroxytryptamines metabolism
Serotonin metabolism
Subjects
Details
- Language :
- English
- ISSN :
- 0361-9230
- Volume :
- 9
- Issue :
- 1-6
- Database :
- MEDLINE
- Journal :
- Brain research bulletin
- Publication Type :
- Academic Journal
- Accession number :
- 7172024
- Full Text :
- https://doi.org/10.1016/0361-9230(82)90128-9