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Effect of potassium depletion on tubular morphology in gentamicin-induced acute renal failure in dogs.
- Source :
-
Laboratory investigation; a journal of technical methods and pathology [Lab Invest] 1982 Dec; Vol. 47 (6), pp. 586-94. - Publication Year :
- 1982
-
Abstract
- Potassium deprivation has recently been reported to potentiate the degree of functional impairment in a gentamicin-induced model of acute renal failure. The present study investigated the effects of two different states of potassium homeostasis on the development of cellular injury in the early stage of gentamicin nephrotoxicity in dogs. Gentamicin (15 mg. per kg. intramuscularly twice daily) was administered for 4 and 7 days to potassium-depleted or potassium-supplemented animals. The results show that potassium supplementation markedly lessens the severity of pathologic alterations induced by gentamicin. In both groups of animals, the S1 and S2 segments of the proximal tubule were the most consistently damaged regions of of the nephron. Potassium-supplemented dogs had a significantly higher number of normal proximal tubule cells than did the animals deprived of potassium and viewed 7 days after gentamicin treatment (77.3 versus 36.9 per cent; p less than 0.025). The degree of total injury to the proximal tubule was significantly higher in potassium-depleted animals than in those supplemented with potassium (59.9 versus 21.9 per cent; p less than 0.05). Only those dogs depleted of potassium prior to the administration of gentamicin had a markedly elevated plasma creatinine level of proximal tubular injury and functional impairment (r = 0.81; p less than 0.005). Potassium supplementation appears to lessen the extent of structural alterations seen in this model of gentamicin-induced acute renal failure in dogs.
- Subjects :
- Acute Kidney Injury pathology
Animals
Creatinine blood
Diet
Dogs
Kidney Cortex pathology
Kidney Cortex ultrastructure
Kidney Tubules ultrastructure
Kidney Tubules, Proximal pathology
Kidney Tubules, Proximal ultrastructure
Male
Microscopy, Electron
Time Factors
Acute Kidney Injury chemically induced
Gentamicins adverse effects
Kidney Tubules pathology
Potassium metabolism
Subjects
Details
- Language :
- English
- ISSN :
- 0023-6837
- Volume :
- 47
- Issue :
- 6
- Database :
- MEDLINE
- Journal :
- Laboratory investigation; a journal of technical methods and pathology
- Publication Type :
- Academic Journal
- Accession number :
- 7144139