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Heparin-induced decrease in circulating antithrombin-III.
- Source :
-
Lancet (London, England) [Lancet] 1977 Sep 17; Vol. 2 (8038), pp. 581-4. - Publication Year :
- 1977
-
Abstract
- Plasma-antithrombin-III (AT-III) concentrations were measured throughout therapy in 24 patients receiving continuous intravenous heparin infusion and in 2 patients treated with repeated intravenous heparin injections. In all patients, including 1 with congenital AT-III deficiency, heparin therapy was associated with a considerable progressive reduction in AT-III-binding capacity and antigenic protein. The net individual decrease in plasma-AT-III was 0-31 +/- 0-05 units/ml (normal plasma-AT-III was 1-00 units/ml) or 9-5 +/- 2-0 mg/dl and the decrease was independent of initial concentration. Plasma-AT-III returned to normal two to three days after heparin was stopped. There was no decrease in plasma-AT-III after a single dose of intravenous heparin. When present in blood for long periods heparin significantly reduced AT-III, the proteinase inhibitor that is responsible for the anticoagulant effect of this drug. The finding is very relevant to the interpretation of clinical data in patients treated with heparin and suggests that AT-III depletion may underly the thromboembolic complications sometimes encountered during heparin therapy.
- Subjects :
- Antigens analysis
Antithrombins analysis
Antithrombins immunology
Binding Sites, Antibody
Coagulants
Dose-Response Relationship, Drug
Epitopes
Heparin pharmacology
Heparin therapeutic use
Humans
Immunoelectrophoresis methods
Infusions, Parenteral adverse effects
Injections, Intravenous
Pulmonary Embolism drug therapy
Thromboembolism chemically induced
Thrombophlebitis drug therapy
Antithrombins antagonists & inhibitors
Heparin administration & dosage
Subjects
Details
- Language :
- English
- ISSN :
- 0140-6736
- Volume :
- 2
- Issue :
- 8038
- Database :
- MEDLINE
- Journal :
- Lancet (London, England)
- Publication Type :
- Academic Journal
- Accession number :
- 71399
- Full Text :
- https://doi.org/10.1016/s0140-6736(77)91429-5