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Progestin and oestrogen receptors in meningiomas. Biochemical characterization, clinical and pathological correlations in 42 cases.
- Source :
-
Acta neurochirurgica [Acta Neurochir (Wien)] 1982; Vol. 64 (3-4), pp. 199-213. - Publication Year :
- 1982
-
Abstract
- Progestin receptors (PR) were evaluated in 40 intracranial and 2 spinal meningiomas. PR measured with radiolabelled R 5020 were found in 93% of cases (39/42). PR levels were significantly higher (p = 0.05) in females (mean: 5,720 fmol/gmT) than in males (mean: 3,120 fmol/gmT). Biochemical characterization of the R 5020 saturable binding sites showed that they were mainly cytosolic, had a high affinity constant (Kd approximately equal to 1 nM) and were progestin specific. Correlation with sex suggested some biological activity of PR in meningiomas. Oestrogen receptors (OR) were evaluated in 36 intracranial and 2 spinal meningiomas. OR measured with radiolabelled R 2858 were present in 79% of cases (30/38). OR mean levels were equal in females (mean: 285 fmol/gmT) and in males (mean: 330 fmol/gmT). The relevance of PR and possibly OR in the biology of meningiomas and of leptomeninges was suggested by the presence of receptors in a sample of normal leptomeninges.
- Subjects :
- Adult
Aged
Aldosterone pharmacology
Dexamethasone pharmacology
Female
Humans
Male
Meningeal Neoplasms pathology
Meningioma pathology
Middle Aged
Receptors, Estrogen metabolism
Receptors, Progesterone metabolism
Meningeal Neoplasms analysis
Meningioma analysis
Receptors, Estrogen analysis
Receptors, Progesterone analysis
Subjects
Details
- Language :
- English
- ISSN :
- 0001-6268
- Volume :
- 64
- Issue :
- 3-4
- Database :
- MEDLINE
- Journal :
- Acta neurochirurgica
- Publication Type :
- Academic Journal
- Accession number :
- 7136865
- Full Text :
- https://doi.org/10.1007/BF01406053