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Progestin and oestrogen receptors in meningiomas. Biochemical characterization, clinical and pathological correlations in 42 cases.

Authors :
Magdelenat H
Pertuiset BF
Poisson M
Martin PM
Philippon J
Pertuiset B
Buge A
Source :
Acta neurochirurgica [Acta Neurochir (Wien)] 1982; Vol. 64 (3-4), pp. 199-213.
Publication Year :
1982

Abstract

Progestin receptors (PR) were evaluated in 40 intracranial and 2 spinal meningiomas. PR measured with radiolabelled R 5020 were found in 93% of cases (39/42). PR levels were significantly higher (p = 0.05) in females (mean: 5,720 fmol/gmT) than in males (mean: 3,120 fmol/gmT). Biochemical characterization of the R 5020 saturable binding sites showed that they were mainly cytosolic, had a high affinity constant (Kd approximately equal to 1 nM) and were progestin specific. Correlation with sex suggested some biological activity of PR in meningiomas. Oestrogen receptors (OR) were evaluated in 36 intracranial and 2 spinal meningiomas. OR measured with radiolabelled R 2858 were present in 79% of cases (30/38). OR mean levels were equal in females (mean: 285 fmol/gmT) and in males (mean: 330 fmol/gmT). The relevance of PR and possibly OR in the biology of meningiomas and of leptomeninges was suggested by the presence of receptors in a sample of normal leptomeninges.

Details

Language :
English
ISSN :
0001-6268
Volume :
64
Issue :
3-4
Database :
MEDLINE
Journal :
Acta neurochirurgica
Publication Type :
Academic Journal
Accession number :
7136865
Full Text :
https://doi.org/10.1007/BF01406053