Inhibition of rat adenocarcinoma metastases by "Staphylococcus aureus" protein A.

Authors :: Cowan FM
Klein DL
Armstrong GR
Ablashi DV
Pearson JW
Bensinger WI
Source :: Biomedicine & pharmacotherapy = Biomedecine & pharmacotherapie [Biomed Pharmacother] 1982 Jan; Vol. 36 (1), pp. 29-31.
Publication Year :: 1982
Abstract: Fischer F 344/CRBL female rats were injected intravenously with 10(6) syngeneic 13,762 adenocarcinoma cells, and daily doses of either 10 micrograms, 100 micrograms or 1 mg Staphylococcus aureus protein A were administered intraperitoneally on days 1 through 11. The animals were sacrificed on day 12, their lungs infused with Bouin's solution, and lung metastases counted. A significant reduction in the number of visible metastatic nodules was observed in the animals given 100 micrograms and 1 mg of Staphylococcus aureus protein A daily.

Subjects :: Adenocarcinoma prevention & control
Adenocarcinoma secondary
Animals
Female
Lung Neoplasms prevention & control
Lung Neoplasms secondary
Neoplasms, Experimental prevention & control
Rats
Rats, Inbred F344
Staphylococcal Protein A administration & dosage
Antineoplastic Agents
Staphylococcal Protein A therapeutic use

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