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Influence of dopamine agonists on plasma and brain levels of homovanillic acid.
- Source :
-
Life sciences [Life Sci] 1982 Jun 14; Vol. 30 (24), pp. 2063-9. - Publication Year :
- 1982
-
Abstract
- The response of the plasma dopamine (DA) metabolite, homovanillic acid (HVA), to two DA agonists was investigated in the rat. Apomorphine administered i.p. (2 mg/kg) produced, within one hour, a significant decrease in plasma HVA. The response of plasma HVA to apomorphine was also investigated after pretreatment with debrisoquin, a drug which selectively blocks peripheral HVA production by inhibition of MAO. Pretreatment with debrisoquin did not significantly alter the decrement in plasma HVA produced by apomorphine indicating that a substantial portion of the plasma HVA response to apomorphine is due to the drug's action on brain. Bromocriptine (2 mg/kg) was also found to produce a significant decrease in plasma HVA. Since the response of brain HVA to DA agonists reflects the sensitivity of the DA receptor, the plasma HVA response to DA agonists might be a practical method of assessing brain DA receptor sensitivity in humans.
Details
- Language :
- English
- ISSN :
- 0024-3205
- Volume :
- 30
- Issue :
- 24
- Database :
- MEDLINE
- Journal :
- Life sciences
- Publication Type :
- Academic Journal
- Accession number :
- 7109836
- Full Text :
- https://doi.org/10.1016/0024-3205(82)90447-7