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Alternatives to beta-blockade in therapy of hypertension with angina pectoris: role of nifedipine or of labetalol.
- Source :
-
British journal of clinical pharmacology [Br J Clin Pharmacol] 1982 Jun; Vol. 13 (1 Suppl), pp. 115S-122S. - Publication Year :
- 1982
-
Abstract
- 1 Patients with combined hypertension and angina pectoris may represent a therapeutic dilemma, with the angina being refractory to conventional beta-blockade. 2 The added benefit of peripheral vasodilation in control of blood pressure is documented in the case of nifedipine. 3 Improved blood pressure control by added nifedipine may not be accompanied by decreased severity of angina pectoris, emphasizing the complex causation of the angina in such patients. 4 The clinically proven added alpha-blocking activity of labetalol distinguishes labetalol from other beta-blockers. However, the suggested benefits of the added alpha-activity in patients with hypertension and angina remain to be proven by further trials in patients.
- Subjects :
- Angina Pectoris complications
Blood Pressure
Drug Therapy, Combination
Exercise Test
Hemodynamics drug effects
Humans
Hypertension complications
Labetalol adverse effects
Angina Pectoris drug therapy
Ethanolamines therapeutic use
Hypertension drug therapy
Labetalol therapeutic use
Nifedipine therapeutic use
Pyridines therapeutic use
Subjects
Details
- Language :
- English
- ISSN :
- 0306-5251
- Volume :
- 13
- Issue :
- 1 Suppl
- Database :
- MEDLINE
- Journal :
- British journal of clinical pharmacology
- Publication Type :
- Academic Journal
- Accession number :
- 7093094
- Full Text :
- https://doi.org/10.1111/j.1365-2125.1982.tb01899.x