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Acetate: inhibitor of growth hormone hypersecretion in diabetic and non-diabetic uraemic subjects.
- Source :
-
Acta endocrinologica [Acta Endocrinol (Copenh)] 1982 Apr; Vol. 99 (4), pp. 551-8. - Publication Year :
- 1982
-
Abstract
- Five diabetic and 14 non-diabetic uraemic patients on long-term haemodialysis were studied during twenty-one 24 h periods including 5 to 7 h of haemodialysis against glucose-free acetate buffered dialysis fluid. Half-hourly blood samples were collected for hormonal and metabolite analysis. In addition, blood samples were analyzed in 40 experiments covering the haemodialysis and a pre-dialysis period. Before dialysis, plasma growth hormone levels were high and fluctuating, but almost always fell to low normal values within the first 2 h of haemodialysis. In the diabetic uraemic patients, the occasional severe hypoglycaemic episodes occurring during haemodialysis did not provoke growth hormone release, and hypoglycaemic reactions were not encountered. Intravenous acetate infusion studies resulted in plasma concentrations ranging from 1.3. to 2.7 mmol, ie. about 60 per cent of the levels reached during haemodialysis and in suppression of growth hormone secretion. It is suggested that the fall in growth hormone levels and the lack of hypoglycaemic symptoms during haemodialysis is due to the use of acetate as a fuel in brain.
- Subjects :
- Acetates blood
Adult
Diabetes Mellitus, Type 1 blood
Diabetes Mellitus, Type 1 complications
Female
Growth Hormone blood
Growth Hormone metabolism
Heparin pharmacology
Humans
Hypoglycemia etiology
Male
Middle Aged
Uremia blood
Uremia complications
Acetates pharmacology
Diabetes Mellitus, Type 1 physiopathology
Growth Hormone antagonists & inhibitors
Renal Dialysis
Uremia physiopathology
Subjects
Details
- Language :
- English
- ISSN :
- 0001-5598
- Volume :
- 99
- Issue :
- 4
- Database :
- MEDLINE
- Journal :
- Acta endocrinologica
- Publication Type :
- Academic Journal
- Accession number :
- 7072453
- Full Text :
- https://doi.org/10.1530/acta.0.0990551