Effect of n-octane and n-nonane administration on alkaline phosphatase activity in tissues of female rats.

Studies on alkaline phosphatase were conducted in albino rats exposed to n-octane or n-nonane for 2 and 7 days; there was an increase in alkaline phosphatase activity of liver, spleen and bone marrow. Increase in spleen alkaline phosphatase activity persisted up to 42 days after single dose of n-octane or n-nonane. Pretreatment with protein synthesis inhibitors, cycloheximide or ethionine removed this observed increase of alkaline phosphatase activity in liver and spleen.