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The in vitro effect of a calf thymus extract (thymostimulin) on the immunologic parameters of patients with untreated Hodgkin's disease.
- Source :
-
Cancer [Cancer] 1982 Jan 15; Vol. 49 (2), pp. 245-50. - Publication Year :
- 1982
-
Abstract
- The in vitro effect of a calf thymus extract, thymostimulin (TP--1), on the E-rosette-forming capacity and on the PHA blastogenic response of peripheral blood lymphocytes was evaluated in 20 patients with untreated Hodgkin's disease. The mean percentage of lymphocytes forming E rosettes increased in patients from 44.2% to 57.5% (P less than 0.005). The mean PHA stimulation index rose with all three concentrations tested, but returned to the normal range only with the highest PHA concentration (60 mu/ml). An increase in the immune parameters was greatest in those patients who presented with decreased E-rosetting cells of total lymphocyte counts or whose disease was Stage III or IV or of mixed cellular histology.
Details
- Language :
- English
- ISSN :
- 0008-543X
- Volume :
- 49
- Issue :
- 2
- Database :
- MEDLINE
- Journal :
- Cancer
- Publication Type :
- Academic Journal
- Accession number :
- 7053826
- Full Text :
- https://doi.org/10.1002/1097-0142(19820115)49:2<245::aid-cncr2820490209>3.0.co;2-7